Association of human leukocyte antigen class II alleles with severe Middle East respiratory syndrome-coronavirus infection
Identifieur interne : 000884 ( Main/Exploration ); précédent : 000883; suivant : 000885Association of human leukocyte antigen class II alleles with severe Middle East respiratory syndrome-coronavirus infection
Auteurs : Ali H. Hajeer ; Hanan Balkhy ; Sameera Johani ; Mohammed Z. Yousef ; Yaseen ArabiSource :
- Annals of Thoracic Medicine [ 1817-1737 ] ; 2016.
Abstract
Middle East Respiratory Syndrome (MERS) is a disease of the lower respiratory tract and is characterized by high mortality. It is caused by a beta coronavirus (CoV) referred to as MERS-CoV. Majority of MERS-CoV cases have been reported from Saudi Arabia.
We investigated the human leukocyte antigen (HLA) Class II alleles in patients with severe MERS who were admitted in our Intensive Care Unit.
A total of 23 Saudi patients with severe MERS-CoV infection were typed for HLA class II, results were compared with those of 161 healthy controls.
Two HLA class II alleles were associated with the disease; HLA-DRB1*11:01 and DQB1*02:02, but not with the disease outcome.
Our results suggest that the HLA-DRB1*11:01 and DQB1*02:02 may be associated with susceptibility to MERS.
Url:
DOI: 10.4103/1817-1737.185756
PubMed: 27512511
PubMed Central: 4966224
Affiliations:
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Hajeer</name><affiliation><nlm:aff id="aff1"><italic>Department of Basic Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia</italic></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><italic>Department of Pathology and Laboratory, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia</italic></nlm:aff></affiliation></author><author><name sortKey="Balkhy, Hanan" sort="Balkhy, Hanan" uniqKey="Balkhy H" first="Hanan" last="Balkhy">Hanan Balkhy</name><affiliation><nlm:aff id="aff3"><italic>Department of Infection Prevention and Control, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia</italic></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"><italic>King Abdullah International Medical Research Center, King Abdulaziz Medical City, Riyadh, Saudi Arabia</italic></nlm:aff></affiliation></author><author><name sortKey="Johani, Sameera" sort="Johani, Sameera" uniqKey="Johani S" first="Sameera" last="Johani">Sameera Johani</name><affiliation><nlm:aff id="aff2"><italic>Department of Pathology and Laboratory, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia</italic></nlm:aff></affiliation></author><author><name sortKey="Yousef, Mohammed Z" sort="Yousef, Mohammed Z" uniqKey="Yousef M" first="Mohammed Z." last="Yousef">Mohammed Z. 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Hajeer</name><affiliation><nlm:aff id="aff1"><italic>Department of Basic Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia</italic></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><italic>Department of Pathology and Laboratory, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia</italic></nlm:aff></affiliation></author><author><name sortKey="Balkhy, Hanan" sort="Balkhy, Hanan" uniqKey="Balkhy H" first="Hanan" last="Balkhy">Hanan Balkhy</name><affiliation><nlm:aff id="aff3"><italic>Department of Infection Prevention and Control, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia</italic></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"><italic>King Abdullah International Medical Research Center, King Abdulaziz Medical City, Riyadh, Saudi Arabia</italic></nlm:aff></affiliation></author><author><name sortKey="Johani, Sameera" sort="Johani, Sameera" uniqKey="Johani S" first="Sameera" last="Johani">Sameera Johani</name><affiliation><nlm:aff id="aff2"><italic>Department of Pathology and Laboratory, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia</italic></nlm:aff></affiliation></author><author><name sortKey="Yousef, Mohammed Z" sort="Yousef, Mohammed Z" uniqKey="Yousef M" first="Mohammed Z." last="Yousef">Mohammed Z. Yousef</name><affiliation><nlm:aff id="aff1"><italic>Department of Basic Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia</italic></nlm:aff></affiliation></author><author><name sortKey="Arabi, Yaseen" sort="Arabi, Yaseen" uniqKey="Arabi Y" first="Yaseen" last="Arabi">Yaseen Arabi</name><affiliation><nlm:aff id="aff4"><italic>King Abdullah International Medical Research Center, King Abdulaziz Medical City, Riyadh, Saudi Arabia</italic></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"><italic>Department of Intensive Care, King Abdulaziz Medical City, Riyadh, Saudi Arabia</italic></nlm:aff></affiliation></author></analytic><series><title level="j">Annals of Thoracic Medicine</title><idno type="ISSN">1817-1737</idno><idno type="eISSN">1998-3557</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>BACKGROUND:</title><p>Middle East Respiratory Syndrome (MERS) is a disease of the lower respiratory tract and is characterized by high mortality. It is caused by a beta coronavirus (CoV) referred to as MERS-CoV. Majority of MERS-CoV cases have been reported from Saudi Arabia.</p></sec><sec id="st2"><title>AIM:</title><p>We investigated the human leukocyte antigen (HLA) Class II alleles in patients with severe MERS who were admitted in our Intensive Care Unit.</p></sec><sec id="st3"><title>METHODS:</title><p>A total of 23 Saudi patients with severe MERS-CoV infection were typed for HLA class II, results were compared with those of 161 healthy controls.</p></sec><sec id="st4"><title>RESULTS:</title><p>Two HLA class II alleles were associated with the disease; HLA-DRB1*11:01 and DQB1*02:02, but not with the disease outcome.</p></sec><sec id="st5"><title>CONCLUSIONS:</title><p>Our results suggest that the HLA-DRB1*11:01 and DQB1*02:02 may be associated with susceptibility to MERS.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van 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Hajeer</name><name sortKey="Johani, Sameera" sort="Johani, Sameera" uniqKey="Johani S" first="Sameera" last="Johani">Sameera Johani</name><name sortKey="Yousef, Mohammed Z" sort="Yousef, Mohammed Z" uniqKey="Yousef M" first="Mohammed Z." last="Yousef">Mohammed Z. Yousef</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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